Evolving understanding of translocator protein 18kDa (TSPO)
نویسندگان
چکیده
منابع مشابه
An Updated View of Translocator Protein (TSPO)
Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys. This protein participates in a variety of cellular functions, including cholesterol transport, steroid hormone synthesis, mitochondrial respi...
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Since it’s serendipitous discovery by researchers over thirty years ago, the translocator protein (18 kDa) (TSPO) has been demonstrated to play an important role in a multitude of critical biological processes. Although implemented as a novel therapeutic and diagnostic tool for a variety of disease states, its most promising role is as a molecular target for anti-cancer treatments such as photo...
متن کاملTranslocator Protein (TSPO) Role in Aging and Alzheimer’s Disease
Cellular damage and deregulated apoptotic cell death lead to functional impairment, and a main consequence of these events is aging. Cellular damage is initiated by different stress/risk factors such as oxidative stress, inflammation, and heavy metals. These stress/risk factors affect the cellular homeostasis by altering methylation status of several aging and Alzheimer's disease associated gen...
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Diabetes mellitus is a chronic disease that is associated with depression. Also, depression is common in adults with type 2 diabetes mellitus (T2DM). Translocator protein (18kDa) (TSPO) and allopregnanolone play an important role in the depression treatment. However, few studies have evaluated TSPO and allopregnanolone in the treatment of depression in T2DM. AC-5216, a ligand for TSPO, produces...
متن کاملStructure-to-function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas
The translocator protein (TSPO), which was previously designated as the peripheral-type benzodiazepine receptor, is a 3.5 billion year-old evolutionarily conserved protein expressed by most Eukarya, Archae and Bacteria, but its organization and functions differ remarkably. By taking advantage of the genomic data available on TSPO, we focused on bacterial TSPO and attempted to define functions o...
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ژورنال
عنوان ژورنال: Pharmacological Research
سال: 2015
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2015.03.022